====== ChemAxon pKa calculator ======

{{:pka.png?800|}}

Calculates protonation constants

==== The pKa calculator generates the following properties ====


**Negative charges:** Number of negative charges on the major microspecies at the given pH

**Positive charges:** Number of positive charges on the major microspecies at the given pH

**Total charge:** Total charge on the major microspecies at the given pH

**Number of charges:** Number of charges on the major microspecies at the given pH

**Strongest acidic pKa:** Lowest acidic pKa

**Strongest basic pKa:** Highest basic pKa

==== Options ====


== Temperature (Kelvin) ==

Calculates pKa values at the given temperature (in Kelvin)

== Tautomerization ==

Consider tautomerization and resonance

== pH ==

Calculates pKa values at the given pH. Not effective in Strongest acidic and basic pKa calculations.
	
== Minimum basic pKa ==

Consider groups with a basic pKa above the given value

== Maximum acidic pKa ==

Consider groups with an acidic pKa below the given value