====== Search analogs for multiple hits by a single search ======

If you have multiple hits containing common structural elements (e.g. multiple analogs of the same scaffold), it make sense to include all your hits in a single search as multiple queries.

  - Go to **[[https://mcule.com/search/screen/?template=multiple-queries-similarity|"FIND CHEMICALS / MULTIPLE QUERY SIMILARITY"]]**
  - Specify your queries in SMILES, mcule ID, InChI or SDF formats (use the tabs on the left to **"Paste text"** or **"Upload file"**)
  - You can set the similarity **"Scoring method"** under **"Advanced options"**: **//Best//** scoring method will pick the similarity score to the most similar query molecule. **//Average//** scoring method will calculate an average similarity score to all query molecules.
  - Under **"Advanced options"** you can also set the **"Descriptor"** used for the similarity search (**OpenBabel Linear Fingerprint**, **OpenBabel MACCS Keys**, **Indigo Similarity Fingerprint**)
  - Click on **"SEARCH"**
  - After the search was finished and the most similar compounds were displayed, click on the orange **"QUOTE"** button in the top right corner
  - Fill out the quote form
  - Click on either **"INSTANT QUOTE"** (quote will be generated on-the-fly - **[[https://mcule.com/pricing/|subscription required]]**) or **"NEXT-DAY QUOTE"** (we will send you a quote by e-mail in 24-48 hours)

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