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--- applications [2013/10/09 22:11] – rkiss
+++ applications [2013/10/11 08:47] – rkiss
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 ====== LEAD OPTIMIZATION ======
-{{:icon_big.png?70|}}
+{{:icon_big.png?65|}}
-Continuously growing set of simple, ready-to use modeling applications specifically designed to evaluate and generate ideas in the lead optimization process.
+Mcule offers a continuously growing set of intuitive, easy-to-use modeling applications specifically designed to evaluate and generate ideas in the hit/lead optimization process. In the course of a drug discovery project, after identifying a hit or lead molecule, the next step is the optimization of multiple properties of the hit/lead. Some of the properties that typically need further optimization are binding affinity to the target, selectivity (affinity to off-targets) and [[http://en.wikipedia.org/wiki/ADME|ADMET]] properties.
 ===== 1-CLICK DOCKING =====
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 **[[toxicitychecker|Learn more >>]]**
+===== IDEA VALIDATOR =====
 Idea validator offers a fully customizable solution to validate and prioritize synthetic ideas. Business rules can be easily implemented. Feature set that can be integrated includes: activity prediction, target profiling, physicochemical property alerts, toxic alerts, commercial availability check
 **[[Ideaval|Learn more >>]]**