Differences

This shows you the differences between two versions of the page.

--- applications [2013/10/11 08:45] – [LEAD OPTIMIZATION] rkiss
+++ applications [2014/01/01 15:26] – flack
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-Continuously growing set of simple, ready-to use modeling applications specifically designed to evaluate and generate ideas in the lead optimization process.
+Mcule offers a continuously growing set of intuitive, easy-to-use modeling applications specifically designed to evaluate and generate ideas in the hit/lead optimization process. In the course of a drug discovery project, after identifying a hit or lead molecule, the next step is the optimization of multiple properties of the hit/lead. Some of the properties that typically need further optimization are binding affinity to the target, selectivity (affinity to off-targets) and [[http://en.wikipedia.org/wiki/ADME|ADMET]] properties.
 ===== 1-CLICK DOCKING =====
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 Molecular docking simulations predict the binding orientation and affinity of a ligand to a target. 1-Click Docking is the easiest molecular docking solution online. It has been designed to quickly test and rank-order ideas of medicinal chemists. Ideas can be prioritized based on the docking scores (predicted binding affinity) and interactions can be visualized between the ligand and the target.
-**[[1clickdocking|Learn more >>]]**
+**[[1clickdocking|Learn more »]]**
 ===== 1-CLICK SCAFFOLD HOP =====
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 **[[Ideaval|Learn more >>]]**