Differences

This shows you the differences between two versions of the page.

--- start [2014/01/01 15:39] – [COMPOUND SOURCING] flack
+++ start [2014/01/01 15:54] – [LEAD OPTIMIZATION] flack
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 ====== LEAD OPTIMIZATION ======
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 Mcule offers a continuously growing set of intuitive, easy-to-use modeling applications specifically designed to evaluate and generate ideas in the hit/lead optimization process. In the course of a drug discovery project, after identifying a hit or lead molecule, the next step is the optimization of multiple properties of the hit/lead. Some of the properties that typically need further optimization are binding affinity to the target, selectivity (affinity to off-targets) and [[http://en.wikipedia.org/wiki/ADME|ADMET]] properties.
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 ====== MCULE DATABASE ======
-__**[[http://mcule.com/database|DOWNLOAD DATABASE]]**__: The Mcule database can be downloaded in SDF format including Mcule IDs and 2D structures from **[[http://mcule.com/database/|HERE]]**. It can be processed in-house and you can come back with the Mcule IDs of the best hits to place an order **[[http://mcule.com/collection/create/from-ids/|HERE]]**.
+**[[http://mcule.com/database|DOWNLOAD DATABASE]]**: The Mcule database can be downloaded in SDF format including Mcule IDs and 2D structures from **[[http://mcule.com/database/|HERE]]**. It can be processed in-house and you can come back with the Mcule IDs of the best hits to place an order **[[http://mcule.com/collection/create/from-ids/|HERE]]**.
 The Mcule database contains high quality molecule collections. All of them passed our in-house developed registration system: **[[regsys|MAC (Mcule Advanced Curation)]]**.