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--- substructuresearch [2012/10/13 17:49] – [Results] sanmark
+++ substructuresearch [2012/10/14 07:34] – rkiss
@@ Line 2: / Line 2: @@
 Substructure search identifies molecules that contains a specific fragment (substructure).
 ===== When to use =====
-Substructure searching is frequently applied for hit exploration. Unlike similarity searching(link)), it outputs only those molecules containing the whole query molecule. It can therefore retrieve close analogs of a particular scaffold (e.g. HTS hit (link) or reference ligand), which can be used to build an initial SAR (structure-activity relationship).
+Substructure searching is frequently applied for hit exploration. Unlike [[similaritysearch|similarity searching]], it outputs only those molecules containing the whole query molecule. It can therefore retrieve close analogs of a particular scaffold (e.g. [[http://en.wikipedia.org/wiki/High-throughput_screening|HTS]] hit or reference ligand), which can be used to build an initial [[http://en.wikipedia.org/wiki/Structure-activity_relationship|SAR]] (structure-activity relationship).
 ===== How to use =====