usecase1csh
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usecase1csh [2013/10/10 16:09] – flack | usecase1csh [2013/12/02 22:26] – link to 1-click scaffold hop's page sanmark | ||
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====== Generate new ideas and eliminate problematic parts by 1-Click Scaffold Hop ====== | ====== Generate new ideas and eliminate problematic parts by 1-Click Scaffold Hop ====== | ||
- | Scaffold hopping is about finding novel active ligands structurally different from a reference ligand (query). Scaffold hopping can be particularly useful during lead optimization to generate new ideas or to eliminate particular parts of your hit/lead to fix IP, toxicity, selectivity or pharmacokinetic issues. 1-Click Scaffold Hop is searching different subsets of **[[purchasable|Purchasable compounds]]** | + | Scaffold hopping is about finding novel active ligands structurally different from a reference ligand (query). Scaffold hopping can be particularly useful during lead optimization to generate new ideas or to eliminate particular parts of your hit/lead to fix IP, toxicity, selectivity or pharmacokinetic issues. |
that might be structurally different but share pharmacophore properties with those of the query. | that might be structurally different but share pharmacophore properties with those of the query. | ||
usecase1csh.txt · Last modified: 2013/12/02 22:28 by sanmark