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--- 1clickscaffoldhop [2013/02/05 08:33] – rkiss
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-====== 1-Click Scaffold Hop ======
-**Identify completely new active scaffolds and leads with a single click!**
-**[[http://www.youtube.com/watch?v=_T2Vx-LM6Bw|WATCH TUTORIAL VIDEO!]]**
-{{:1click_sh.png?800|}}
--Click Scaffold Hop is the simplest online solution for scaffold hopping.
-Scaffold hopping: identifying novel and diverse scaffolds starting from a single reference ligand
-====== When to use ======
-Hit identification: find novel actives by using a single reference ligand (ligand-based virtual screening)
-Lead optimization: replace parts of lead molecules to fix IP, toxicity, selectivity, pharmacokinetic issues
-====== How to use ======
-Draw a known active ligand and jump to a new active scaffold by clicking on Scaffold Hop! To understand why the two molecules are similar click on “Visualize similarity” when browsing the results. **[[http://www.youtube.com/watch?v=_T2Vx-LM6Bw|Click here]]** for a tutorial video.
-Have a nice hopping!