Search analogs for multiple hits (one hit at a time)
If your hits are from fairly different scaffolds, it might make more sense to run separate similarity searches on each of them, merge the results into a single compound collection, and request a quote for the merged collection.
Specify your first query (either by drawing or by providing a chemical identifier such as mcule ID, SMILES, InChI or InChIKey)
If you want to keep a particular substructure in all resulting analogs, modify your query accordingly (delete unnecessary parts) and select “Substructure” search type. Note: you can block substituents at particular positions of the molecule by placing explicit hydrogen atoms.
If you simply want the overall most similar analogs of your compound, select “Similarity” search type